Pulmonary depostion and retention of inhaled aerosols.

by Theodore Frederick Hatch

Publisher: AcademicP

Written in English
Published: Pages: 192 Downloads: 888
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Edition Notes

Series"American Industrial Hygiene Association, and United States. Atomic Energy Commission Division of Technical Information. Monographseries
ContributionsGross, Paul.
The Physical Object
Pagination192p.,ill.,24cm
Number of Pages192
ID Numbers
Open LibraryOL18894526M

The purpose of this study was to assess the effects of elastase-induced pulmonary emphysema and the inhalation of an irritant aerosol (Triton X, a nonionic surfactant similar to those used in a number of pressurized consumer products) on pulmonary deposition and retention of an insoluble test aerosol, /sup 59/FE-labeled Fe/sub 2/O/sub 3/. Retention at h and 24 h (R24) was reduced following the exercise vs. the resting exposure, consistent with greater bronchial deposition during exercise. The product of DFL and R24 gave a measure of fractional burden at 24 h (B24), i.e., the fraction of inhaled aerosol residing in . Deposition of inhaled fibrous particles in the human lung. J. Aerosol Med., ;– CrossRef Google Scholar Bailey MR, Hodgson A, Smith H. Respiratory tract retention of relatively insoluble particles in rodents. Title:Aerodynamics and Deposition Effects of Inhaled Submicron Drug Aerosol in Airway Diseases VOLUME: 7 ISSUE: 1 Author(s):Md. Faiyazuddin, Md. Mujahid, Talib Hussain, Hefazat H. Siddiqui, Aseem Bhatnagar, Roop K. Khar and Farhan J. Ahmad Affiliation:Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New .

The pulmonary retention of soluble CeCl/sub 3/ and insoluble CeO/sub 2/ was similar but much greater for insoluble CeF/sub 3/. This study determines the disposition of NP aerosols inhaled by rats. Theoretical models of respiratory tract deposition of inhaled particles are compared to experimental studies of deposition patterns in humans. 2. Particle Deposition in the Respiratory Tract and the Effect of Respiratory Disease. 3. Mathematical Modeling of Inhaled Therapeutic Aerosol Deposition in the Respiratory Tract. 4. Lung Transporters and Absorption Mechanisms in the Lungs. 5. Bioavailability of Inhaled Compounds. 6. 3D Models as Tools for Inhaled Drug Development. 7.   Substantial paclitaxel deposition and retention resulted in an order of magnitude increase in dose-normalized pulmonary exposure over IVnP. Inhaled NanoPac arms had an order of magnitude lower plasma C max than IVnP, but followed a similar plasma T 1/2 clearance (quantifiable only to 72 hours postadministration). Pulmonary histopathology found. and the velocity at which aerosol particles are emitted from a device and travel through the airways also have a strong impact on pulmonary deposition patterns. Generally, faster inhalation results in increased central and mouth-throat region deposition, whereas slower inhalation results in more peripheral deposition patterns. However, when using.

  Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys. 12(2), – ().Medline, CAS, Google Scholar; 25 Son YJ, Longest PW, Tian G, Hindle M. Evaluation and modification of commercial dry powder inhalers for the aerosolization of a submicrometer excipient enhanced growth (EEG) formulation. Here, we report on lung deposition, retention and clearance, and translocation of nm radiolabeled carbon particles in three study groups: healthy volunteers, cigarette smokers, and patients with chronic obstructive pulmonary disease (COPD). Cigarette smokers and patients with COPD are believed to be especially susceptible to inhaled particles. (). The effect of alveolar mixing on particle retention and deposition investigated by a dynamic single-path model. Aerosol Science and Technology: Vol. 54, No. 9, pp.   Get this from a library! Aerosol Inhalation: Recent Research Frontiers: Proceedings of the International Workshop on Aerosol Inhalation, Lung Transport, Deposition and the Relation to the Environment: Recent Research Frontiers, Warsaw, Poland, September , [J C M Marijnissen; L Gradoń;] -- A group of highly esteemed aerosol scientists - physicists, chemists, biologists and.

Pulmonary depostion and retention of inhaled aerosols. by Theodore Frederick Hatch Download PDF EPUB FB2

Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both. Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both the physical and biological aspects of the Edition: 1.

Pulmonary Deposition and Retention of Inhaled Aerosols [Hatch, Theodore F., and Paul Gross] on *FREE* shipping on qualifying offers. Pulmonary Deposition and Retention of Inhaled AerosolsCited by: Pulmonary deposition and retention of Pulmonary depostion and retention of inhaled aerosols. book aerosols, [Theodore F.

Gross, Paul, ; American Industrial Hygiene Association. ; U.S. Atomic Energy Commission. Hatch Author: Hatch, Theodore F. Gross, Paul, ; American Industrial Hygiene Association.

; U.S. Atomic Energy Commission. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by : Stephen B.

Sulavik. Pulmonary Deposition and Retention of Inhaled Aerosols Book Description: Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both the physical and biological aspects of the subject.

Leonard Greenburg “PULMONARY DEPOSITION AND RETENTION OF INHALED AEROSOLS”, American Journal of Public Hea no. 9 (September 1, ): pp. DOI: /AJPHa Recommend this Journal to your library.

The book is written for doctors and engineers—for the people who are interested in controlling dusty environment and preventing pulmonary disease as a result of inhalation. Pulmonary Deposition and Retention of Inhaled Aerosols.

(PMCID:PMC) Full Text Citations ; BioEntities ; Related Articles ; External Links ; Yale J Biol Med. October; 37(2): – PMCID: PMC Pulmonary Deposition and Retention of Inhaled Aerosols. "Pulmonary Deposition and Retention of Inhaled Aerosols." American Review of Respiratory Disease, 92(2), p.

By Theodore F. Hatch, Paul Gross, George D. Clayton. ISBN ISBN Pulmonary Deposition and Retention of Inhaled Aerosols is worried with the respiration deposition and retention of inhaled aerosols, beginning with preliminary consumption and concluding with occasions that precede pathological tissue reaction, drawing both upon either the.

Book: Pulmonary Deposition and Retention of Inhaled Aerosols. + pp. Abstract: This is the first of a series of books prepared by the American Cited by: Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both the physical and biological aspects of the subject.

The book opens with an introductory chapter on the relationship between the dose of. Since most inhaled aerosols are polydisperse in nature (see previous section ), it is important to understand the relative role of the different deposition mechanisms in overall deposition.

FIG. Deposition mechanisms of inhaled particle in the lung. Sites of deposition are illustrative but can also occur in other areas of the lung. Pulmonary Deposition: Determinants and Measurement Techniques. the characteristics of the aerosol, most importantly size, the physiology of the animal, most importantly breathing pattern, and.

As freon is limited in its use as a generator for aerosol inhalation, powder particles are used as an alternative for inhalation therapy. The pulmonary deposition and clearance of inhaled powder particles was studied by positron emission tomography (PET) in ten patients with chronic obstructive pulmonary disease (COPD) and in five normal controls.

The powder, 5 microm in mean diameter, was. Deposition, retention, and clearance of inhaled particles Br J Ind Med. Nov;37(4) The distribution of the deposition sites of inhaled particles is strongly dependent on their aerodynamic diameters.

For normal man, inhaled non-hygroscopic particles greater than or equal to 2 micrometers that deposit in the conducting airways by. Deposition and retention of inhaled 67 Ga 2 O 3 aerosols, with volume equivalent dia. of and μm, were measured in Beagle dogs.

The total deposition was 39 ± 19% and 53 ± 24% of the inhaled and μm aerosols respectively, while alveolar deposition was 25 and 32% respectively. Pulmonary drug delivery is an applied aerosol science, which facilitates the treatment of both lung and systemic disease.

Inhalation of aerosols can be an efficient way to treat diseases; however the lung has evolved anatomical and physiological barriers which serve to exclude inhaled particulates from reaching the respiratory airways. Pulmonary Deposition and Retention of Inhaled Aerosols Theodore F.

Hatch The book opens with an introductory chapter on the relationship between the dose of an inhaled aerosol and the kind and degree of response, and classification of particulate substances.

Deposition and Retention of Ultrafine Aerosol Particles in the Human Respiratory System. standing and estimating local and regional deposition of inhaled particles in There are many approaches to calculating the deposition of aerosol particles in the pulmonary region of human lungs.

For ultrafine particles, local gas. The aim of the present study was to characterize amphotericin B aerosols nebulized by ultrasonic and jet nebulizers and to study their deposition and pharmacokinetics in patients with pulmonary mycetoma. The aerodynamic behaviour and pulmonary deposition of amphotericin B particles were measured using a direct isotopic method based on stable labelling of the drug with 99mTc.

Silver nanoparticle deposition/retention to the lung lobes after 1-day (6-h) exposure. Silver nanoparticle deposition/retention per lobe is shown in Table nanoparticles were retained to RCr (right cranial lobe), RM (right middle lobe), RCa (right caudal lobe), RA (right accessory lobe), and LL (left lung) for,%, and % of total lung deposits/retention.

Palmes ED, et al: Effect of chronic obstructive pulmonary disease on rate of deposition of aerosols in the lung during breathholding, in Walton WH (ed): Inhaled Particles III.

Surrey, England, Unwin Bros Ltd,pp This body of literature has been recently summarized in a number of consensus documents on the management of asthma and chronic obstructive pulmonary disease (COPD), the two most prominent pulmonary disorders.

In these statements, the important role of inhaled drugs in the treatment of these disorders has been unequivocally reported. Section I reviews the anatomy and physiology of human lung.

Section II describes the pulmonary response to dust in terms of airway changes and reactions to silica. Sections III and IV deal with lung clearance in animals, the retention, penetration, and elimination of inhaled dusts, and lung deposition and clearance in human.

ALTSHULER B, PALMES ED, YARMUS L, NELSON N. Intrapulmonary mixing of gases studied with aerosols. J Appl Physiol. May; 14 (3)– MORROW PE. Some physical and physiological factors controlling the fate of inhaled substances. Deposition. Health Phys. May; – Deposition and retention of inhaled 67 Ga 2 O 3 aerosols were measured in ten beagle dogs to provide reasonable estimates for human deposition and in Fischer rats and CD-I mice to estimate lung burdens in small animals frequently used in toxicological evaluations.

Aggregated particles of 67 Ga 2 O 3, µm mass median diameter (MMD), were produced using heat treatment of 67 Ga. Pulmonary particle deposition Darquenne () [7] -Mechanisms affecting the transport and deposition of aerosols in the lungs -Link between the therapeutic effects of inhaled drugs and their.

In lung dosimetry of inhaled particulate compounds one has to consider both deposition and clearance kinetics throughout the respiratory tract. The deposition is governed essentially by particle size, ventilatory parameters, as well as airway characteristics, whereas the clearance of particulate compounds, once deposited, is dependent on physicochemical characteristics of the compound.

Lobar evenness of deposition/retention in rat lungs of inhaled silver nanoparticles: an rats were exposed nose-only for 1 or 5days (6h/day) to an aerosol of 20nm well-dispersed silver nanoparticles (AgNPs), which is the desired particle diameter resulting in maximum deposition in the pulmonary region when inhaled as singlets.

After exposure.Mice-to-men comparison of inhaled drug-aerosol deposition and clearance Respir Physiol Neurobiol. Feb; Combined with the deposition model, the particle retention and clearance kinetics of deposited nanoparticles indicates that the clearance rate from the mouse lung is higher than that in the human lung.

Pulmonary Ventilation.inhalation of small aerosol boluses delivered to shallow volumetric depths in the lung has been used to study particle clearance from the bronchial airways (16, 19).This technique may also be useful for delivering aerosolized drugs to the bronchial epithelium when alveolar deposition is undesirable ().An aerosol bolus is a discrete volume of air containing particles sandwiched within an.